Impaired Mitochondrial Oxidation in Diabetes
The Importance of Injury as a Cause of Impaired Mitochondrial
Oxidation in Diabetes
John P. Cleary, M.D.
In diabetes, glucose metabolism via the Krebs cycle is impaired, and
this leads to reduced cellular energy and elevated blood sugar
levels. When a cell is damaged by oxidation injury, cytosol NAD
levels fall and ATP levels decrease, If the DNA strand breaks can be
repaired, and the cell regains lost NAD, the energy system can
function again, but frequently cell death ensues
…Elevated blood glucose is therefore due to impaired membrane
transport of glucose into cells and into the mitochondria of the
cells where it is metabolized into energy, Impaired transport could
lead to further deficient energy levels inside the cell…
…The combination of excessive gluconeogenesis with absent fatty
acid formation leads to body wasting. Very little metabolism of
glucose for energy production occurs in the diabetic. What does occur
is mostly in the brain, which can use only glucose and in emergency
the kettle body beta hydroxybutarate can be used to make energy.